Experts suggest the U.S. has a strategic opportunity to leverage Iran's weakened position for a nuclear deal after Israel's targeted strikes on Iranian nuclear and military sites.

The Iranian and Israeli strikes mark the most sustained, direct attacks ever between the two rivals. Three people were killed in Israel and at least 78 in Iran, officials said.

Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.

Trump told the Wall Street Journal that he knew all about Israel’s plan ahead of time, that he wasn’t given a mere “heads-up.”

Iran and Israel exchanged more deadly missile strikes overnight Friday after Israel mainly attacked Iranian nuclear and military targets one day earlier.

Iranian officials have repeatedly denied seeking a nuclear weapon. The United States and Iran have held five rounds of negotiations toward achieving an agreement that would limit Iran's nuclear activities in exchange for sanctions relief, with a sixth round of talks scheduled for Sunday.