Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3′ end processing of both nucleus-encoded (nu-tRNAs) and mitochondria ...
Decoupling tRNA promoter and processing activities enables specific Pol-II Cas9 guide RNA expression
Spatial/temporal control of Cas9 guide RNA expression could considerably expand the utility of CRISPR-based technologies. Current approaches based on tRNA processing offer a promising strategy but ...
The ribosome, that protein-making machine, relies on other, smaller machines. For example, it works in concert with a mechanism that supplies amino-acid-carrying tRNAs, including tRNAs that require ...
To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where they read the genetic instructions from messenger RNA, mRNA, and deliver the ...
The fruit fly lacks the tRNA nuclear export receptor Exportin-t, which only exports end-processed tRNAs to the cytoplasm to ensure the completion of the processing steps in the nucleus. The related ...
tRNA is an important component of the biological synthesis of new proteins, as it carries a specific amino acid that will be incorporated to the protein through the ribosome machinery, as directed by ...
Raghu R. Chivukula, MD, PhD, a physician-investigator in the Departments of Medicine & Surgery and the Center for Genomic Medicine at Massachusetts General Hospital and Harvard Medical School, is the ...
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