The AHA recommended whole exome or whole genome sequencing as first-line diagnostic tools for mitochondrial diseases.

Many vertebrates exhibit marked population cycles when periods of population growth end, with population crashes eliminating a large number of individuals. The Common Murre Uria aalge is an example of ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...

A new study from deCODE genetics uses pedigrees and sequence data from 64,806 Icelanders to shed light on the rate and nature of mutations in mitochondrial DNA (mtDNA) and the peculiar dynamics of its ...

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

Mitochondria act as energy factories in cells and have their own, separate DNA. Mutations to mitochondrial DNA (mtDNA) have been observed in cancer, but it has been unclear how these changes might ...

A research team has identified a molecular target that could open up new therapeutic options to treat aging-associated diseases like Parkinson's. Scientists at the University of Cologne have ...

You are a forensic scientist recruited to help solve a long-standing "missing persons" case. Mitochondrial DNA, or mtDNA for short, is the key to your success. Take careful notes as your teacher ...

When a four-year-old boy was brought to the Cincinnati Children’s Hospital Medical Center with fatigue, muscle pain and muscle weakness, doctors suspected there might be something wrong with his ...