IT has been reported that catechol-o-methyl transferase (COMT) is found in most organs of the rat except skeletal muscle 1. In the course of studies on the isolation of this enzyme from various ...

BECAUSE both norepinephrine and sympathetic stimulation produce vasoconstriction there has been much speculation about the role of norepinephrine in essential hypertension. Hypertensive patients have ...

Ongentys is an oral, selective and reversible inhibitor of catechol-O-methyltransferase. Ongentys® (opicapone) has been made available by Neurocrine Biosciences as an adjunctive treatment to ...