This lab includes the complete titration procedure used to investigate how well a buffer resists changes in pH. Prepare a buffer solution by accurately calculating and measuring the required amounts ...

Biopharmaceutical production depends on buffers. Making sure the right buffer solutions are available, in the right place on the manufacturing line, at the right time, and in the right quantity, is a ...

Designed specifically for bioreactor-scale workflows, the Krakatoa (R) K500 requires less than 15 minutes of hands-on time and produces up to 500 liters in less than three hours. Two standard pod ...

In-line buffer management markedly reduced the production bottlenecks and manufacturing costs inherent in biopharmaceutical manufacturing. Additional cost reductions are possible, however, by ...

The importance of precise buffer design in bioprocessing cannot be overstated. Buffers, aqueous solutions tasked with controlling pH in drug manufacturing processes, serve as the unsung heroes, ...

This lab includes a theoretical explanation of how buffers work and how they are made, including a derivation of the Henderson-Hasselbalch equation. Students will use what they have learned to ...

Recently, the trend of outsourcing buffer manufacturing system has been adopted by pharmaceutical companies as it reduces the cost of buffer formulation, eliminates space and temperature maintenance ...

Antibodies are subject to instability issues due to chemical and physical instabilities and these effects can change the pharmacokinetics of the antibody. For this reason, produced antibodies must be ...

Biopharma companies often lack the capacity and infrastructure to handle large buffer volumes needed for mAb production. Avantor offers four key strategies to improve operational efficiencies and ...