The length of telomeres that protect the ends of our chromosomes should be tightly regulated. Those that are too long predispose to cancer, and those that are too short lose their protective ability, ...

New findings describe how the enzyme CST is recruited to the end of the telomere, where it maintains telomere length with the help of subtle chemical changes made to the protein POT1. The length of ...

Longer leukocyte telomere length is associated with higher left ventricular mass (LVM) and larger global ventricular size, as well as better cardiac function and lower risk of heart failure (HF). The ...

Heritable pathogenic defects in genes related to mitosis and telomere function may specifically increase the risk for sarcomas – rare cancers that develop in muscles, bones, and other connective ...

Much the way the caps on the ends of a shoelace prevent it from fraying, telomeres - regions of repetitive DNA sequences and a protein structure - protect the tips of chromosomes from damage. Every ...

Telomere shortening — a sign of cellular aging — is associated with multiple changes in the brain associated with dementia, whereas longer telomeres associate with better brain health and lower risk ...

Researchers at Arizona State University’s (ASU) School of Molecular Sciences and the Biodesign Institute’s Center for the Mechanism of Evolution have discovered an unprecedented pathway producing ...

Given that developing animals are generally more sensitive to heat, and telomeres function in similar way across species, our results could extend to many other birds and mammals. More research is ...

CST (purple/lavender) bound to POT1 (red). Phosphorylation of the crimson-highlighted region in POT1 regulates the recruitment and activity of CST–Polα-primase at telomeres. The length of telomeres ...