Mutations in the tumor suppressor TP53 are a common cause of cancer, making the altered protein an attractive target for therapeutics. Among them, the Y220C mutation is the ninth most frequent and it ...

If tumor suppressor genes get turned off due to mutations, cells are at risk of becoming cancerous and growing uncontrollably. Most cancer cells have more than 60 mutations. A challenge for ...

In a recent perspective published in the journal Cell Death and Differentiation, researchers in France, Germany, and Sweden discussed the unique mutational spectrum of the transformation-related ...

CAMBRIDGE, MA -- Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.