This is a preview. Log in through your library . Abstract Loss of chromosome 18q21 is well documented in colorectal cancer, and it has been suggested that this loss targets the DCC, DPC4/SMAD4, and ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, No. 9 (Apr. 25, 2000), pp. 4820-4825 (6 pages) Biological signals for transforming growth factor β (TGF-β ) ...

A new research paper was published in Oncotarget, Volume 16, on May 8, 2025, titled "METTL3 promotes oral squamous cell carcinoma by regulating miR-146a-5p/SMAD4 axis." In this study, researchers ...

Figure 8: Schematic representation of METTL3-mediated OSCC progression via regulating the miR-146a-5p/SMAD4 axis. Overexpressed METTL3 (an oncogene) in OSCC cells enhances the processing of ...

Cetuximab, an anti-EGFR monoclonal antibody and the only FDA-approved targeted therapy against advanced head and neck squamous cell carcinoma (HNSCC), has limited efficacy due to development of ...

Survival outcomes of sustained MR4.5 in patients with chronic myeloid leukemia (CML) treated with various tyrosine kinase inhibitors (TKI). Long-term survival of patients with therapy-related MDS ...

Researchers have found a way to help make chemotherapy more effective in treating colon cancer. They identified a new pathway (RICTOR/mTORC2) as a biological target for the disease. Targeted ...

Prostate tumors that carry a "signature" of four molecular markers have the potential to become dangerously metastatic if not treated aggressively, researchers now report. The discovery lays the ...

Researchers have uncovered another clue behind the causes of cleft palate and the process that leads to palate formation. Researchers at the University Of Southern California School Of Dentistry have ...