The insulin receptor (IR) is a prototypical receptor tyrosine kinase that orchestrates critical cellular processes, including metabolism, cell growth and differentiation. Activation of the IR involves ...

Drug discovery is shifting from static snapshots to moving pictures. Instead of inferring how medicines work from end results ...

Nerve growth factor receptor TrkA (in green) and co-receptor NRP1 (in purple) are coexpressed in the same nerve cells in mice. Researchers at the NYU Pain Research Center have found a new receptor for ...

A team has demonstrated new mechanisms that are involved in the development of inflammatory cardiovascular diseases. A team led by LMU researchers Christian Weber and Yvonne Döring has demonstrated ...

Many people are familiar with histamine, a biological molecule that serves as a key driver of allergic reactions and other ...

According to new research, T cells have a nuclear receptor doing something very odd—but very important—to help them fight pathogens and destroy cancer cells. This receptor, called retinoic acid ...

Researchers uncover a hidden nanoscale mechanism critical for Met receptor activation, providing a new blueprint for targeted ...

A genetic mutation passed from mother to children in families affected by schizophrenia has now been shown to completely silence a brain receptor that pharmaceutical companies are racing to target ...

A deep dive into the scientific shift toward multi-target obesity therapeutics and its implications for metabolic health and ...

The histamine H3 receptor typically becomes active upon binding to one of its agonists, such as histamine itself. This, in ...