In clinical trials with sequential patient entry, fixed sample size designs are unjustified on ethical grounds and sequential designs are often impracticable. One solution is a group sequential design ...

A recent study has shown that a more flexible approach to study design can significantly improve the efficiency of preclinical research. The translation of preclinical research findings into effective ...

A class of sequential designs for estimating the percentiles of a quantal response curve is proposed. Its updating rule is based on an efficient summary of all of the data available via a parametric ...