The development of analytical technology that allows investigation of the diversity of cells that form biological tissues based on molecular information is important to elucidate the heterogeneity of ...
Around the same time, Mack Fulwyler, an engineer working at Los Alamos National Laboratory, needed to separate particles, so he drew on existing techniques to create droplets to separate cells from a ...
Fluorescence-based flow cytometry has been a workhorse in the single-cell analysis of surface markers, intracellular cytokines, intranuclear proteins (such as transcription factors) and cell cycle.
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