The ubiquitin ligase SCFFBXL5 tags internalized α-synuclein fibrils for destruction. Without the ligase, cultured human cells cannot clear this material. In mice, the ligase prevents injected fibrils ...
Cuiyan Zhang, Xiaotong Li, Guillaume Adelmant, Jessica Dobbins, Christoph Geisen, Matthew G. Oser, Kai W. Wucherpfenning, Jarrod A. Marto, William G. Kaelin Jr. Proceedings of the National Academy of ...
Regulated protein degradation contributes to plant development by mediating signaling events in many hormone, light, and developmental pathways. Ubiquitin ligases recognize and ubiquitinate target ...
Like a well-run city, healthy cells recycle their waste, breaking down and reusing damaged proteins. In the January 29 Nature, scientists led by Jeffrey Bode and Jacob Corn at the Swiss Federal ...
The genetic connections between DNA repair pathways and human cancer predisposition have fueled interest in the proteins that recognize and repair specific sites of DNA damage. The repair enzymes are ...
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