During DNA replication, the two new DNA strands are synthesized asymmetrically, with the leading strand synthesized in a continuous fashion and the lagging strand synthesized as a discontinuous series ...

DNA replication stress is incurred by endogenous or environmental challenges to replication fork progression that impede faithful genome duplication. Genomic G-quadruplexes (G4s) are DNA secondary ...

We now know a bit more about an important step in this complex biological process." An enduring mystery of 'lagging strand' DNA replication The DNA replication process is carried out by multiple ...

Embryonic stem (ES) cells are pluripotent stem cells that can produce all cell types of an organism. ES cells proliferate rapidly and have been thought to experience high levels of intrinsic ...

If you are anything like us, whenever you plan a journey, you spend a remarkable amount of time thinking about the start and ...

Researchers have gained a clearer insight into how common alterations to the structure of DNA affect the process of DNA replication. These structural changes can put a stop to replication, causing ...

Researchers shed new light on G-quadruplexes, a type of secondary DNA structure that has attracted attention as a potential therapeutic target in cancer. Every day, billions of cells in your body ...

During replication, DNA polymerases are positioned on each strand of DNA . Using a microscope slide as an anchor, we tethered DNA to a bead and stretched it with a flow of solution. We tracked how the ...