The chaperonin system is pivotal in maintaining cellular proteostasis through its ATP-dependent mediation of protein folding. Among these, the TRiC/CCT complex has emerged as a key molecular machine ...

Membrane proteins constitute a significant fraction of cellular proteomes and play indispensable roles in signalling, transport, and metabolism. Their folding and subsequent stability are not only ...

No gene acts alone: interacting variants and protein partnerships can worsen, mask or even rescue disease risk, demanding ...

Cellular membrane proteins play important roles in cellular transport, signaling, and cell-to-cell communication. Malfunction in membrane proteins can lead to serious diseases, such as cancer. However ...

Researchers have developed a method to evaluate the folding stability of a million proteins simultaneously. DNA libraries were used to generate protein -- DNA complexes that were treated with enzymes ...

Researchers from Northwestern University and the Institute for Industrial Science at the University of Tokyo say they have developed a new high-throughput approach known as cDNA display proteolysis to ...

Demis Hassabis (CEO of Deep Mind) and John M. Jumper have useed artificial intelligence to predict the structure of almost all known proteins. David Baker has learned how to master life’s building ...

When a protein folds, its string of amino acids wiggles and jiggles through countless conformations before it forms a fully folded, functional protein. This rapid and complex process is hard to ...

For those outside the chemistry cognoscenti, the announcement might have seemed little more than researchers patting each other on the back. But the question of protein folding had plagued scientists ...

A new statistical model demonstrates the ability to correctly predict the folding mechanisms for both small and large proteins. The function of a protein is determined by its structure. From the rigid ...

New computer simulations that model every atom of a protein as it folds into its final three-dimensional form support the existence of a recently identified type of protein misfolding. Proteins must ...