Protein denaturation refers to the disruption of a protein’s native conformation, which is critical for its biological function. When proteins are subjected to external stresses such as changes in ...

A designer version of the tau protein, developed by a team led by UT Southwestern Medical Center researchers, maintains its ...

Identifying conditions that maximize the structural stability of a biologic’s native state is essential for developing therapeutics, formulations, and process development conditions. In this GEN ...

Researchers have identified a backup mechanism of protein quality control which prevents the toxic effects of protein aggregation in specific tissues when normal methods of molecular monitoring fail.

The accumulation of misfolded proteins in the brain is central to the progression of neurodegenerative diseases like Huntington's, Alzheimer's and Parkinson's. But to the human eye, proteins that are ...

There are many different tools, both old and new, for characterizing proteins. For ranking and comparing the stability of biologics and formulations, the most established tools rely on temperature ...

Parkinson's disease (PD) is an age-related, progressive neurodegenerative disorder. The hallmark of PD pathogenesis is the Lewy bodies (LBs) that accumulate in neurons in the substantia nigra region ...

The COVID-19 pandemic brought about by the severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) led to the disruption of the global economy and the loss of human lives. Studies are still ...

Controlled heat treatment can provide a powerful and flexible tool to enhance wheat flour for cake production.

A research team reviewed the process of gel formation in fermented sausages, emphasizing the crucial role of myofibrillar proteins and the influence of lactic acid bacteria, temperature, and ...