Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene expression patterns, are essential for proper skin development, according to a paper published in ...

Most of our genome is often written off as “junk DNA”, meaning it doesn’t encode for genes that get made into proteins. This so-called junk consists of accumulated DNA elements like viral DNA that got ...

A mounting body of evidence is uncovering how the polycomb group (PcG) proteins play a key role in the initiation, development, and progression of cancer in humans. Image Credit: ibreakstock / ...

The existence of transgenerational epigenetic inheritance has now been demonstrated among Drosophila fruit flies. By temporarily modifying the function of Polycomb Group (PcG) proteins--which play an ...

Polycomb-repressive complexes (PRCs) play key roles in development by repressing a large number of genes involved in various functions. Much, however, remains to be discovered about PRC-silencing ...

Latest discovery could improve development of future stem cell therapies and cancer treatments. Mount Sinai researchers have discovered that Polycomb complexes, groups of proteins that maintain gene ...

Prostate cancer becomes fatal when associated with metastasis. In the October 10 Nature, Sooryanarayana Varambally and colleagues describe a microarray-based analysis of genes whose expression is ...

Xigang Liu, Lei Gao, Thanh Theresa Dinh, Ting Shi, Dongming Li, Ruozhong Wang, Lin Guo, Langtao Xiao and Xuemei Chen It has been perplexing that DNA topoisomerases, enzymes that release DNA supercoils ...

Two Polycomb complexes have been found to act together to control the development of skin and can cover for each other if one complex is damaged. A recent study led by researchers at the Icahn School ...

A multi-institutional study has discovered spontaneous mutations in RNF2 (RING2) gene as the underlying cause of a novel neurological disorder. This Undiagnosed Diseases Network (UDN) study was led by ...