The mitochondrial chaperone TRAP1 is a key regulator of cellular homeostasis and its activity has important implications in neurodegeneration, ischemia and cancer. Recent evidence has indicated that ...

In simple terms: a mutation is a stable change in genetic sequence that can be copied when cells or viruses replicate. Most mutations have no detectable effect, some contribute to disease, and a small ...

Adaptive immunity is a central defence system essential for long-term and highly specific protection against pathogens through the precise molecular recognition of antigens by lymphocytes. However, ...

Tumors can carry mutations in hundreds of different genes, and each of those genes may be mutated in different ways—some mutations simply replace one DNA nucleotide with another, while others insert ...

As language models learn to interpret words in a sentence, protein language models learn how amino acids work together within a protein. Konstantina Tzavella, who used artificial intelligence in her ...

In humans, hundreds of proteins interact in a complex network dubbed the interactome. Those interactions are further complicated when disease-causing mutations are introduced into genes that code for ...

Researchers found a way to screen cancer-linked gene mutations much more easily and quickly than existing approaches, using a variant of CRISPR genome-editing known as prime editing. Tumors can carry ...