Please provide your email address to receive an email when new articles are posted on . The majority of drug interactions today are attributed to the cytochrome P450 (CYP450) isoenzyme system. However ...

Researchers have mapped the conformational changes that occur in a protein 'notorious' for pumping chemotherapeutic drugs out of cancer cells and blocking medications from reaching the central nervous ...

In recent years, the issue of potential drug-drug interactions (DDI) occurring when pharmaceuticals are co-administered has become a subject of increasing recognition. The high frequency of DDIs is ...

One of the well-established mechanisms of multidrug resistance (MDR) to chemotherapy in cancer patients is ATP binding cassette (ABC) transporter overexpression in cancer cell membrane, and as the ...

Keeping brain amyloid-β (Aβ) levels in check means controlling both the means of production and the method of disposal. On the disposal side, a few years ago researchers recognized for the first time ...

WHEN CANCERS STOP responding to chemotherapy, one of the culprits is a protein transporter that expels drugs out of diseased cells, thereby preventing the benefits of treatment. Now researchers are ...

(Nanowerk News) Researchers have tried for decades to understand the undulations and gyrations that allow transport proteins to shuttle molecules from one side of a cell membrane to the other. Now ...

Long-Term Follow-Up of Patients Treated With Paclitaxel/Carboplatin-Based Chemotherapy for Advanced Non–Small-Cell Lung Cancer: Sequential Phase II Trials of the Minnie Pearl Cancer Research Network ...