Anxiety is often described as a whole‑brain problem, but a series of mouse experiments suggests that, in some cases, a single ...

“This is a paradigm shift,” says Donn Van Deren, PhD, postdoctoral research fellow at the University of Pennsylvania, who ...

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

The blood-brain barrier border protects the brain by regulating the flow of molecules, peptides, and cells, but it also keeps out many therapeutics. Now, researchers have harnessed the power of a ...

Brain macrophages serve diversified niches in the brain to maintain the organ’s homeostasis, and can play pathogenic roles in age-related brain disease. Hoping to one day replace dysfunctional ...

Irvine, Calif., April 21, 2025 — A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer’s disease and other neurological disorders, according to ...

Anxiety disorders are some of the most common mental health conditions in America, affecting about one in five people nationwide. But much remains unknown about the roots of anxiety in the brain. Now, ...

Genetic neurodegenerative disorders like Tay-Sachs and Sandhoff disease currently have no effective treatments. A possible strategy is replacing affected cells with healthy ones in order to slow the ...

During development, there are known sex-related differences in how microglia function. But into adulthood, there was thought to be less variation in how they behave. Microglia maintain neuronal ...

A new way to deliver disease-fighting proteins throughout the brain may improve the treatment of Alzheimer's disease and other neurological disorders, according to scientists. By engineering human ...