Recent studies have shown variation in the gene-expression profile and phenotype of microglia across brain regions and between different age and disease states. But the molecular mechanisms that ...

Glioblastoma, the most common and most aggressive brain tumor type in adults, remains difficult to treat because it can infiltrate surrounding brain tissue and spread far beyond the main tumor.

Abnormal microglial energy metabolism in AD. Translocation of Aβ into microglial mitochondria by the outer membrane translocase (TOM) impairs mitochondrial function and inhibits phagocytosis. TREM2 ...

In a recent study published in Cell, researchers examined 152,459 microglial transcriptomes from 443 individuals, identifying 12 transcriptional states and their relationship to Alzheimer's disease ...

A study by researchers from Fujita University reveals that hypernatremia enhances NFAT5 and NO production in microglia and minocycline mitigates this response. The image above is a schematic showing ...

In diseases driven by dysfunctional microglia, could replacing them with healthy versions prevent, or even reverse, pathology? Yes, suggest two papers in the June 18 Neuron. Both describe how mice ...

In Alzheimer’s disease, microglia pack on fat, which impairs phagocytosis. Now, scientists led by Christiane Ruedl of Nanyang Technological University, Singapore, report that blocking lipid buildup in ...

Scientists discovered that lowering a specific molecule helps microglia switch into a protective state that quiets brain inflammation in Alzheimer’s. A small group of these cells seems to have an ...

It all started with genetic data. A gene here, a gene there. Eventually the story became clearer: If scientists are to one day find a cure for Alzheimer's disease, they should look to the immune ...