A tissue section from a mouse model of lung metastasis showing cancer cells (green) that have attracted and activated fibroblasts (red) to support the growth of a metastatic tumor. Image: Massagué Lab ...

When it comes to cancer metastasis, it takes two to tango. That was one of the key findings of a new study led by researchers at Memorial Sloan Kettering Cancer Center (MSK): The TGF-beta and RAS ...

The quantification issues related to comparisons of matched primary tumors and metastases assessed using CGH, fluorescence in situ hybridization (FISH), and mutation analyses are more straightforward.

Metastasized melanoma cells in the brain mark the end stages of the cancer’s progression. The process by which the cells get to the brain is a complex one but a new study has identified one of the ...

Cancer becomes far more dangerous when it spreads beyond its original site. Some cancers stay in one place, while others ...

Researchers have been working to better understand what drives melanoma brain metastasis. They now report on the identification of a cell signaling pathway that regulates the metastatic spread of ...

A recent study has uncovered the molecular mechanisms behind osteocyte death in melanoma bone metastasis, revealing that ferroptosis—an iron-dependent form of cell death—plays a central role in the ...

According to the National Cancer Institute, nearly 1.7 million new cases of cancer were diagnosed in the US last year, and 600,000 will die from the disease. Approximately 39.6% of men and women will ...

Most people with breast and other cancers die not from the primary tumor but from metastasis, when the cancer spreads throughout the body. Researchers have developed a compound that blocks the actions ...