There exists a unique and clinically relevant time course of urinary drug delivery for a loop diuretic at which the natriuretic response is optimized. This rate of drug delivery resides on the steep ...
Most accepted pharmacologic treatments for heart failure are supported by evidence from large clinical trials. In contrast, evidence from large, well-controlled clinical trials to guide the use of ...
Big clinical trials of loop diuretics for keeping patients stable after discharge from a heart-failure (HF) hospitalization have been in short supply, so firm guideline recommendations on the matter ...
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