These factors prompted research into better and more permanent treatments for T1D. The most obvious solution: restore the natural repertoire of β cell islets. Although most recipients experienced ...

An international team of researchers led by Max Delbrück Center Scientific Director Professor Maike Sander, MD, has for the first time developed an organoid model of human pluripotent stem ...

Pancreatic beta cells (β-cells) reside in a cluster of cells in the pancreas known as the islets of Langerhans. Pancreatic β cells are the only cells that produce insulin - a hormone that decreases ...

Zimislecel is an allogeneic stem cell–derived islet-cell therapy. Data on the safety and efficacy of zimislecel in persons with type 1 diabetes are needed. We conducted a phase 1–2 study of zimislecel ...

Incretin polypeptides are gut-derived hormones released after food intake that potently enhance insulin secretion from pancreatic islet β-cells. The incretin effect is the foundation for blockbuster ...

The late stages of the development of T1DM, characterized by stabilization and maintenance of insulitis or, in some cases, its resolution, are probably dominated by the adaptive immune response.

T1D is an autoimmune disorder characterized by immune-mediated destruction of insulin-producing pancreatic β-cells, resulting in absolute insulin deficiency. Insulin, often termed the metabolic key, ...

"Remarkably, we found that R-VECs did adapt when co-transplanted with islets, supporting the islets with a rich mesh of new vessels and even taking on the gene activity "signature" of natural islet ...