Integrins are heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix and engage bidirectional signalling across the plasma membrane. Activation is controlled by ...

A research team led by Junior Associate Professor Masato Nakagawa (Department of Life Science Frontiers) investigated the effects of basic fibroblast growth factor (bFGF) and its interactions with ...

Integrins are heterodimeric transmembrane receptors that mediate adhesion between cells and the extracellular matrix, orchestrating bidirectional signalling that governs cancer cell behaviour. In the ...

Globally, human hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related mortality. The worldwide incidences of HCC have been on the rise in recent ...

Integrin alpha-5 (ITGA5) is a central modulator of extracellular matrix signaling and has been tied to fibrosis and tissue damage, contributing to lupus nephritis (LN) pathogenesis. A group of ...