You can embed a PDF file into a cell of an Excel worksheet and then use Excel's security features to lock the object. This allows you to take advantage of both technologies.

You can have Excel make a spreadsheet in read only format for others, so that people can read its contents but not edit them, or you can enforce other content restrictions.

The PDF File has been inserted into an Excel sheet as an object similar to a chart or any shape. We can drag it or resize it as we want. Repeat the same steps to insert more PDF files into the sheet.

Microsoft announced this week that's it's now possible for Office 365 users to import table data from Adobe Portable Document Format (PDF) files into the Microsoft Excel spreadsheet program.