For decades, the central dogma of molecular biology—DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease. This model explained ...

Our genes contain all the instructions our body needs to function, but their expression must be finely regulated to guarantee that each cell performs its role optimally. This is where DNA and RNA ...

Multiple forms of double-stranded RNA (blue, magenta, orange structures) cross cell membranes with the help of a conserved protein located in novel sites (colored by depth) throughout the roundworm's ...

A forested hill and clouds are in the background of an image of a shallow pool of steaming water, with the ground underneath colored in shades of beige, red, and brown. Life may have first emerged in ...

RNA plays a vital role in how our genes are expressed and how diseases develop. Yet, because RNA molecules constantly change shape, understanding how they work has long been a major scientific ...

Fred Hutch researchers invent a CRISPR screening method to understand RNA-binding proteins often mutated in cancer and other diseases In biology’s standard tale of two acids — deoxyribonucleic (DNA) ...

More than four billion years ago, Earth was a very different place. Pools of water froze and thawed in cycles, minerals shaped reactions, and molecules bumped into each other by chance. Out of this ...

Increasing paternal age has been linked to elevated health risks for the next generation, including higher risks of obesity and stillbirth. But what drives this increased risk remains unknown. Most ...

When scientists sliced into a block of Siberian permafrost and pulled out a woolly mammoth nicknamed Yuka, they expected to ...

Ancient DNA has been pulled from a permafrost-preserved woolly mammoth found in Siberia, and scientists are thrilled. They recovered and sequenced RNA, a fragile molecule that many biologists assumed ...