The peripheral immune system can promote either immunity or tolerance when presented with new antigens. Dendritic cells (DCs) have a crucial role in determining immune outcomes by acquiring antigens, ...
IDO inhibitor/anti-PD1 combinations are much better tolerated than anti-PD1/CTLA-4. Currently tested IDO inhibitors have a differential mechanism of action and varying potency. Efficacies of IDO/PD-1 ...
Identification of novel liquid biopsy biomarker for monitoring the immune set point in both solid tumor and hematological malignancy patients. This is an ASCO Meeting Abstract from the 2018 ASCO-SITC ...
Indoleamine 2,3 dioxygenase (IDO) activity during pregnancy protects developing fetuses from maternal immune responses in CBA mice. We show here that fetal allografts were rejected only in mating ...
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