This method uses polymer modifications to tune enzyme activity for increased solubility in non-native solvents. Tuning the miscibility of enzymes in non-native solvent environments has important ...

Sanofi has developed a simpler way to create site-specific antibody-to-mannose-6-phosphate (M6P) conjugates that eliminates the need for enzyme remodeling. This more straightforward method makes M6P ...

Proteins are the workers in a cell and, as the "basic element of life", are responsible for the most widely varying metabolic processes. In plants, for example, they take on an important function in ...

After a long search, RIKEN researchers have identified an enzyme crucial for keeping lipid-linked sugar chains in check in yeast cells. This finding, published in the Journal of Cell Biology, reveals ...

Archaeosine is synthesized via three steps in tRNA. ArcS, the second-step enzyme, transfers a lysine to preQ 0, which is introduced into tRNA by ArcTGT, the first-step enzyme. The resultant preQ 0-Lys ...

This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...

Study reveals that reversible chemical modifications can inhibit pyruvate kinase and affect its variants differently, ...

An analysis of an unusual enzyme could result in a new generation of antimicrobial medicines to counter antibiotic resistance. Key details in the enzyme-driven biosynthesis of a natural molecule with ...