Computational biologists from the National University of Singapore (NUS) have uncovered how RNA splicing—a crucial process for isoform expression and protein diversity—is regulated across different ...

Alternative splicing is a genetic process where different segments of genes are removed, and the remaining pieces are joined together during transcription to messenger RNA (mRNA). This mechanism ...

Scientists engineered human cells to perform binary calculations using genetic circuits, advancing cell therapies and ...

"Nevertheless, our cells can produce several hundred thousand different proteins," explains Prof. Ivan Đikić from the Institute of Biochemistry II at Goethe University Frankfurt. This diversity is ...

Researchers at Hebrew University use RNA trans-splicing to program cells for disease detection ...

The utility of long reads is well documented in studying complex genomic regions, structural variation, epigenetic modifications, and transcriptomics. More specifically, long read data are increasing ...

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After a decade of work, scientists have completed a molecular model of the human spliceosome, an incredibly complex cellular machine. When an active gene is expressed in a cell, it is transcribed into ...

Treating acute myeloid leukemia (AML) depends on knowing what goes wrong inside cells. A new study suggests that two genetic mutations—IDH2 and SRSF2—work cooperatively to mis-splice RNA messages and ...

Computational biologists from the National University of Singapore (NUS) have uncovered how RNA splicing – a crucial process for isoform expression and protein diversity - is regulated across ...