T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on ...

A type of light-sensitive cell in one of the visual systems of fruit flies transmits two chemical messengers, histamine and acetylcholine, in response to the same light signal. These two molecules act ...

BIRMINGHAM, Ala. – Transduction is the changing of one form of energy into another, such as a spoken voice changed into radio waves by a cellphone. Ten years ago, three research teams published a ...

The gray portion of this schematic represents a nanodisc, where for the first time researchers were able to replicate the native membrane environment (red dots) of a T-cell receptor (cyan). One of the ...

Researchers created a tool capable of comprehensively mapping crucial interactions underlying drug efficacy in one superfamily of cell receptors. One in every three FDA-approved drugs targets a single ...

Innate immune sensors—known as pattern recognition receptors (PRRs)—detect specific molecular components of bacterial or viral intruders. The PRRs forward the signals which results in the production ...

Chimeric antigen receptor (CAR) T cell therapy is a promising immunotherapy against cancer. The idea is to fortify a person’s immune system to fight its own battle by boosting T cells with the ability ...

Researchers from Karolinska Institutet have discovered that the genes encoding our T cell receptors vary greatly between persons and populations, which may explain why we respond differently to for ...

Cells typically contain a cytoskeleton, which helps shuttle things around and provides structural integrity, among other functions. Microtubules are important parts of the cytoskeleton, and new ...

Scientists have built functional cancer-fighting immune cells directly inside living animals, skipping the expensive and time-consuming process of extracting a patient’s cells and engineering them in ...

Ten years ago, three research teams published a breakthrough — the first description of the molecular mechanism for transduction in fingertip sensory Merkel cells that can transduce gentle touch, a ...