The pumping action of the calcium pump protein—an intricate molecular machine with several moving parts that helps control muscle contraction—has been detailed with exquisite precision by RIKEN ...
The plasma membrane calcium pump (PMCA) is an essential ATP-driven enzyme that extrudes Ca2+ from the cytosol to maintain low resting intracellular Ca2+ levels. Four major isoforms display distinct ...
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First comprehensive transport model of a plasma membrane calcium pump could inform new drug development
We've all heard the advice: "Drink your milk and you will have strong bones and healthy teeth." It's supposed to help us meet our bodies' high calcium requirements. However, our cells keep calcium ...
Figure 1: Structures of calcium pump before (left) and after (right) it has transported ions into the sarcoplasmic reticulum (A, N, P: three cytoplasmic domains; TM ...
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