Key to understanding the basis for a disease is to define its cell of origin and what drives that cell to become pathologic. Further, to understand the LCH cell of origin, one needs to place it in the ...

Brain tumors are the most common solid tumor of children and the most common cause of cancer-related deaths. The poor overall outcome of this patient population results from three major issues: 1) The ...

Mutationally activated BRAF is expressed in melanoma, glioblastoma, thyroid, lung and colon cancers and in a subset of haematological malignancies. The most common BRAF mutation leads to the ...

BRAF-positive metastatic malignant melanomas develop resistance to treatment with drugs targeting the BRAF/MEK growth pathway through a major change in metabolism, new research shows. The findings ...

New research overseen by University of Colorado Cancer Center member Rebecca Schweppe, PhD, could lead to improved treatment for people with thyroid cancer characterized by a mutation in the BRAF gene ...

MIAMI, FLORIDA (EMBARGOED UNTIL MAY 25, 2023, AT 5 P.M. ET) – An early-phase study led by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine ...

The initiating oncogenic event in half of human lung adenocarcinomas is still unknown, a fact that complicates the development of selective targeted therapies. Researchers have demonstrated that the ...

An altered structure that 'mimics' the active form of BRAF Around half of all cancers are associated with dysfunction of the MAPK pathway, a communication system that enables cells to integrate ...