A federal judge once again blocked the National Institutes of Health from moving forward with its plans to cap reimbursements for costs indirectly related to research—a measure that would have cost colleges at least $4.3 billion.

The National Institutes of Health cannot impose an across-the-board cap on indirect costs it pays research universities and medical schools, under a federal court order Wednesday in cases brought by Democratic attorneys general and university associations.

A federal judge on Wednesday issued a nationwide preliminary injunction blocking the Trump administration from slashing National Institutes of Health payments for research overhead, a decision that suggests plaintiffs seeking to overturn the sweeping policy change are likely to eventually succeed.